Hybrid necrosis as plant autoimmunity
Arabidopsis hybrid necrosis is a Dobzhansky–Muller incompatibility driven by autoimmune NB-LRR conflict.
Source
Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants
What they did
Mapped necrotic Uk-1×Uk-3 hybrids, introgressed DM1/DM2, and linked the phenotype to NB-LRR immune gene mismatch.
What they found
DM1 (Chr5, Uk-3) and DM2 (Chr3, Uk-1) are necessary and sufficient; phenotype fully penetrant at 16°C and suppressed at 23°C.
The limits
What it doesn't show
Does not prove every plant hybrid incompatibility is autoimmune.
Key terms
- Dobzhansky–Muller
- Incompatibility from epistatic allele combinations.
- Hybrid necrosis
- Autoimmune-like hybrid failure phenotype.
- DM1/DM2
- Dangerous Mix loci causing necrosis.
- NB-LRR
- Nucleotide-binding LRR immune receptor.
- Epistasis
- Phenotype depends on allele combination.
- Introgression
- Moving a locus into another genetic background.
Flashcards
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Quiz yourself
DM1 chromosome:
Common questions
DM1 source/chromosome?
Uk-3, Chromosome 5.
DM2 source/chromosome?
Uk-1, Chromosome 3.
Temp control?
Necrosis at 16°C; suppressed at 23°C.
Mechanism class?
Autoimmune NB-LRR incompatibility.
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