Hybrid necrosis as plant autoimmunity
Arabidopsis hybrid necrosis is a Dobzhansky–Muller incompatibility driven by autoimmune NB-LRR conflict.
Source
Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants
Study at a glance
- Design
- Animal / in-vitro — Genetic mapping of necrotic Uk-1×Uk-3 Arabidopsis hybrids to NB-LRR mismatch loci
- N
- Plant hybrid incompatibility genetics; penetrance temperature-dependent — no single sample N
- Population
- Arabidopsis thaliana hybrid and introgression lines (Uk-1×Uk-3)
- Outcome
- DM1/DM2 necessity for autoimmune hybrid necrosis
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
Hybrid necrosis as plant autoimmunity
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Necrosis fully penetrant at 16°C.
The compromised phenotype was fully penetrant at 16 °C, a habitat temperature typical for A. thaliana in the wild [], but could be conveniently suppressed at 23 °C, allowing seeds to be obtained for genetic analysis.
DM1?
The DM1 (DANGEROUS MIX 1) locus was derived from Uk-3 and mapped to Chromosome 5
What they did
Mapped necrotic Uk-1×Uk-3 hybrids, introgressed DM1/DM2, and linked the phenotype to NB-LRR immune gene mismatch.
What they found
DM1 (Chr5, Uk-3) and DM2 (Chr3, Uk-1) are necessary and sufficient; phenotype fully penetrant at 16°C and suppressed at 23°C.
The limits
What it doesn't show
Does not prove every plant hybrid incompatibility is autoimmune.
Key terms
- Dobzhansky–Muller
- Incompatibility from epistatic allele combinations.
- Hybrid necrosis
- Autoimmune-like hybrid failure phenotype.
- DM1/DM2
- Dangerous Mix loci causing necrosis.
- NB-LRR
- Nucleotide-binding LRR immune receptor.
- Epistasis
- Phenotype depends on allele combination.
- Introgression
- Moving a locus into another genetic background.
Flashcards
0 of 10 answers reviewed
Research intelligence for this paper
See its role on concept claims, tensions it is part of, placement history, and related discoveries.
Quiz yourself
DM1 chromosome:
Common questions
DM1 source/chromosome?
Uk-3, Chromosome 5.
DM2 source/chromosome?
Uk-1, Chromosome 3.
Temp control?
Necrosis at 16°C; suppressed at 23°C.
Mechanism class?
Autoimmune NB-LRR incompatibility.
More on Natural selection