Immune transcriptome of bacteria-challenged sea bass
Deep RNA-seq of bacteria-challenged Lateolabrax japonicus reveals innate immune genes.
Source
Deep sequencing-based transcriptome profiling analysis of bacteria-challenged Lateolabrax japonicus reveals insight into the immune-relevant genes in marine fish
Study at a glance
- Design
- Animal / in-vitro — RNA-seq of head kidney/spleen from bacteria-challenged vs mock-challenged sea bass
- N
- Tissue RNA pooled from 15 fishes per preparation — no unpooled individual analytic N
- Population
- Lateolabrax japonicus (Japanese sea bass)
- Outcome
- Immune-related transcriptome after bacterial challenge
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Immune transcriptome of bacteria-challenged sea bass
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Lateolabrax japonicus (sea bass).
Fish immunogenetics has received considerable attention due to its essential role in understanding the origin and evolution of immune systems [-].
Bacteria-challenged versus mock.
Further, it is also beneficial in the creation of immune-based therapy of severe fish diseases.
What they did
RNA-seq of head kidney/spleen from bacteria- versus mock-challenged fish; assembled immune transcripts.
What they found
Large transcriptome with many immune effectors and pathway annotations (hepcidin, lysozyme, RAG).
The limits
What it doesn't show
Homology-based pathway calls; not a vaccine efficacy trial.
Key terms
- Head kidney
- Teleost immune organ.
- Innate immunity
- Rapid non-adaptive defense.
- Hepcidin
- Antimicrobial peptide.
- RAG
- Recombination-activating genes.
- DGE
- Digital gene expression.
- Teleost
- Bony fish.
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Topic:
Common questions
Species?
L. japonicus.
Tissues?
Head kidney/spleen.
Contrast?
Bacteria vs mock.
Focus?
Immune genes.
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