Topic
Innate immunity research, explained
9 open-access innate immunity studies, each with a flashcard deck and a quiz.
- Which sensor starts IFN against SARS-CoV-2 in lung cells?
SARS-CoV-2 triggers delayed IFN mainly via MDA5/LGP2 sensing of viral intermediates, with IRF3/IRF5/NF-κB p65 as key TFs.
- Was innate immunity already complex in early animals?
Anthozoan cnidarians retain much ancestral metazoan immune/signaling complexity; flies and worms lost many components.
- How interferon throttles sterol synthesis in antiviral defense
Type I interferon couples viral sensing to down-regulation of the sterol pathway’s mevalonate–isoprenoid arm, limiting viral growth.
- Plant TIR domain binds viral elicitor
Tobacco N protein’s TIR domain is critical for association with TMV p50 elicitor.
- Coral gene expression in white syndromes
White-syndrome lesions in Acropora hyacinthus show distinct innate-immunity–related expression versus healthy tissue.
- Chicken β-defensin gene cluster
Chicken genome encodes 13 β-defensin (Gal) genes in a single innate-immunity cluster.
- How do E. coli vesicles talk to gut epithelium?
Outer membrane vesicles from probiotic and commensal E. coli deliver ligands that activate NOD1-mediated immune responses in intestinal epithelial cells.
- Immune transcriptome of bacteria-challenged sea bass
Deep RNA-seq of bacteria-challenged Lateolabrax japonicus reveals innate immune genes.
- Does caspase-11 pyroptosis feed atherosclerosis?
Integrating GEO data, ox-LDL macrophages, and ApoE−/− mice, the authors show caspase-11/GSDMD pyroptosis inflames plaques; deleting caspase-11 or AAV-suppressing GSDMD shrinks lesions, and human caspase-4 mRNA tracks coronary severity.