Which sensor starts IFN against SARS-CoV-2 in lung cells?
SARS-CoV-2 triggers delayed IFN mainly via MDA5/LGP2 sensing of viral intermediates, with IRF3/IRF5/NF-κB p65 as key TFs.
Source
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
Study at a glance
- Design
- Animal / in-vitro — Lung epithelial infection + RNA-sensor/TF screens
- N
- N=16 · 16 putative sensors screened
- Population
- Lung epithelial cells infected with SARS-CoV-2
- Outcome
- Sensors/TFs governing IFN induction
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Which sensor starts IFN against SARS-CoV-2 in lung cells?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
16 sensors screened.
By screening 16 putative sensors involved in sensing of RNA virus infection, we found that MDA5 and LGP2 primarily regulate IFN induction in response to SARS-CoV-2 infection.
Delayed IFN in lung epithelium.
Here, we find that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells.
What they did
Infected lung epithelial cells and screened candidate RNA sensors and transcription factors for IFN induction.
What they found
Delayed IFN; MDA5 and LGP2 primary sensors; viral intermediates activate MDA5 pathway; IRF3, IRF5, NF-κB/p65 key TFs.
The limits
What it doesn't show
In-vitro epithelial circuits may differ from whole-lung immune networks in patients.
Key terms
- MDA5
- Cytosolic RNA sensor central to IFN induction here.
- LGP2
- RIG-I-like receptor co-regulator of sensing.
- IFN response
- Interferon antiviral program.
- Viral intermediates
- Replication-derived RNAs triggering MDA5.
- IRF3/IRF5
- Interferon regulatory transcription factors.
- NF-κB/p65
- Inflammatory TF subunit highlighted here.
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Primary sensors:
Common questions
Main sensors?
MDA5 and LGP2.
IFN timing?
Delayed.
Sensors screened?
16.
Key TFs?
IRF3, IRF5, NF-κB/p65.
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