Mediterranean diet and depression risk
Overall Mediterranean diet assignment did not significantly reduce depression; a nuts arm suggested benefit in diabetes subgroup analyses.
Source
Mediterranean dietary pattern and depression: the PREDIMED randomized trial
What they did
PREDIMED randomised high-CVD-risk adults to MD-EVOO, MD-nuts, or low-fat control and tracked incident depression.
What they found
224 depression cases (median 5.4 years). Merged MD HR 0.85 (NS). MD-nuts nonsignificantly inverse overall; significant benefit in DM2 subgroup.
The limits
What it doesn't show
Depression was not the original primary endpoint; subgroups can be chance findings.
Key terms
- PREDIMED
- Randomised Mediterranean diet trial.
- MD-nuts
- Mediterranean diet plus nuts.
- MD-EVOO
- Mediterranean diet plus EVOO.
- Incident depression
- New depression in follow-up.
- Hazard ratio
- Relative risk vs control.
- Subgroup analysis
- Analysis in a participant subset.
Flashcards
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Merged HR:
Common questions
Cases?
224.
Merged HR?
0.85 NS.
Follow-up?
5.4 years.
DM2?
Significant MD-nuts benefit.
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