Topic
Depression treatment research, explained
16 open-access depression treatment studies, each with a flashcard deck and a quiz.
- Deprexis online therapy reduced depression scores
An integrative online program (Deprexis) improved BDI depression symptoms versus delayed treatment in a large German internet RCT.
- Mediterranean diet and depression risk
Overall Mediterranean diet assignment did not significantly reduce depression; a nuts arm suggested benefit in diabetes subgroup analyses.
- How was UK mental health in the first COVID lockdown weeks?
Among 3097 UK adults in April 2020, depression, anxiety, and stress exceeded population norms, especially in younger people, women, and COVID-19 risk groups.
- Can lay counsellors deliver one flexible therapy for many problems?
Refugees treated by briefly trained local counsellors using a mix-and-match therapy improved far more on depression and trauma symptoms than people waiting for treatment.
- Can short online self-help courses reduce depression?
Two guided online self-help courses, one based on CBT and a shorter one based on problem solving, both reduced depressive symptoms more than waiting, with medium-sized effects and no clear winner between them.
- Diet quality and depression risk
In the SUN cohort, higher adherence to Mediterranean, pro-vegetarian, and AHEI-2010 diet scores tracked with lower risk of incident depression over about 8.5 years.
- Can a CBT phone app help stubborn depression?
Adding a smartphone CBT program to a medication switch improved depressive symptoms more than switching antidepressants alone.
- Wine, alcohol, and depression
In PREDIMED adults, low-to-moderate alcohol—especially wine—associated with lower incident depression risk versus abstaining, while heavy drinking looked riskier.
- Does smoking track with depression in US adults?
In NHANES 2005–2018, daily smokers had ~2.4× the odds of PHQ-9 depression vs never smokers; longer cessation tracked lower odds.
- iCBT for depression in diabetes
Unmodified clinician-supported iCBT beat treatment-as-usual on depression, anxiety, distress, and diabetes-specific distress in adults with diabetes.
- Do daily-living limits track depression in older Chinese adults?
Among 9,789 CHARLS adults ≥60, ~43.5% had high-risk CES-D scores; BADL and IADL limitations roughly tripled adjusted depression odds.
- Depression linked to C. difficile infection risk
Adults with major depression had higher CDI rates, and specific antidepressants plus living alone/widowhood also associated with infection risk.
- Antidepressant adverse events cohort
In 238,963 adults aged 20–64 with depression, most used antidepressants and several common agents associated with higher fall rates versus non-use.
- Can FGF21 calm LPS-triggered despair in mice?
rhFGF21 (0.75–3 mg/kg) improved OFT locomotion and cut FST/TST immobility after LPS 0.83 mg/kg, lowered IL-1β/TNF-α/IL-6 and NF-κB, and lost benefit with FGFR1 inhibitor PD173074.
- Can docking find new NMDA blockers for Alzheimer’s?
A pharmacophore-docking-MD pipeline screened ZINC against GluN2B NMDA receptors and nominated six compounds with better predicted solvation binding than ifenprodil—still untested in cells or people.
- Do gabapentinoids track with later dementia?
Among 206,802 Taiwanese adults, gabapentin or pregabalin use was linked to higher dementia incidence (980 vs 605 per 100,000 person-years; aHR 1.45), with aHR 3.16 under age 50 and a cumulative-dose gradient.