Cord-blood PFBS linked to preeclampsia in Shanghai
Among Shanghai births, higher standardized cord PFBS associated with preeclampsia (AOR 1.81) and overall hypertensive disorders of pregnancy (AOR 1.64) in a dose-response pattern.
Source
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy
Study at a glance
- Design
- Cohort — Shanghai delivery cohort with cord-blood PFAS and recorded hypertensive disorders of pregnancy
- N
- N=687 · 687 women delivering singletons at two Shanghai hospitals (13 excluded for missing covariates in some models)
- Population
- Women delivering at two Shanghai hospitals, 2011–2012
- Outcome
- Hypertensive disorders of pregnancy and preeclampsia related to cord PFAS (esp. PFBS)
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Cord-blood PFBS linked to preeclampsia in Shanghai
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
HDP, preeclampsia, and gestational hypertension risks were 6.1%, 2.8%, and 3.3%.
The risk of gestational hypertension, preeclampsia and overall HDP was 3.3, 2.8, and 6.1%, respectively, in our study.
Standardized PFBS AOR was 1.64 for HDP and 1.81 for preeclampsia.
one unit increase in standardized PFBS concentration was associated with a higher risk of HDP [Adjusted odds ratio (AOR): 1.64, 95% CI: 1.09–2.47], and preeclampsia (AOR: 1.81, 95% CI: 1.03–3.17).
What they did
Authors recruited women delivering at two Shanghai hospitals, quantified eight PFAS in cord blood, classified HDP/preeclampsia from records, and used elastic-net then unpenalized logistic models with confounder adjustment.
What they found
HDP, preeclampsia, and gestational hypertension rates were 6.1%, 2.8%, and 3.3%. PFOA was the highest median PFAS (6.98 ng/ml) but PFBS (median 0.047 ng/ml) was selected for HDP/preeclampsia. AOR 1.64 for HDP and 1.81 for preeclampsia per standardized PFBS unit.
The limits
What it doesn't show
Cord blood is not a full pregnancy-long exposure history, and observational AORs cannot prove PFBS causes preeclampsia.
Key terms
- PFBS
- Short-chain perfluorobutane sulfonate, a PFOS replacement found in cord blood.
- Hypertensive disorders of pregnancy (HDP)
- Gestational hypertension, preeclampsia, chronic hypertension, or superimposed preeclampsia.
- Preeclampsia
- New hypertension with organ injury in pregnancy; major cause of maternal/perinatal morbidity.
- Elastic net
- Penalized regression that selects among correlated PFAS while shrinking noise.
- Cord-blood PFAS
- PFAS measured at delivery in umbilical cord plasma as a prenatal exposure marker.
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PFAS linked to preeclampsia here:
Common questions
Which PFAS associated with preeclampsia?
PFBS, despite low median concentration.
Preeclampsia AOR per standardized PFBS?
1.81 (95% CI 1.03–3.17).
HDP rate in the sample?
6.1%.
Highest-concentration PFAS?
PFOA (median 6.98 ng/ml).
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