Serum phthalates track adipose redox markers
In 308 Spanish adults, low-molecular-weight phthalates associated with higher GPx and TBARS in fat, while a phthalate mixture index associated with lower GSH and GSSG.
Source
Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort
Study at a glance
- Design
- Cross-sectional — GraMo surgery patients with serum phthalates and adipose oxidative-stress biomarkers
- N
- N=308 · 308 with adipose redox markers; 143 with overlapping exposure and markers; 230 with serum phthalates
- Population
- Spanish adults undergoing surgery in the GraMo study
- Outcome
- Adipose oxidative-stress biomarkers associated with serum phthalates and mixtures
Structured fields used in claim comparison tables when every cited study has a complete layer.
What they did
GraMo surgery patients had 32 serum phthalate metabolites measured by LC–MS/MS and nine oxidative-stress biomarkers assayed in adipose; robust regression and weighted quantile sum (WQS) mixture models were fit.
What they found
MEP was the most abundant metabolite. Several LMWP metabolites (MMP, MiBP, MnBP) associated positively with GPx and TBARS, whereas HMWP MiNP associated negatively. The WQS index associated with lower GSH (β = −30.089) and GSSG (β = −19.591); MEHP and MECPP dominated the GSH mixture.
The limits
What it doesn't show
Cross-sectional surgery sample cannot establish temporality; adipose 8OHdG was only available for 112 people; short-lived phthalates make a single serum sample a noisy exposure metric.
Key terms
- Phthalates
- Plasticizer chemicals grouped as low- vs high-molecular-weight parent diesters.
- LMWP vs HMWP
- Low- vs high-molecular-weight phthalates used in cosmetics vs PVC plasticizers.
- GPx / TBARS
- Glutathione peroxidase activity and lipid-peroxidation products in adipose.
- WQS index
- Weighted quantile sum mixture score of co-occurring phthalate metabolites.
- GraMo cohort
- Granada surgical patients providing adipose and serum for pollutant studies.
Flashcards
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Quiz yourself
Adipose redox markers were measured in how many people?
Common questions
How many people had adipose redox markers?
308 participants; 143 had both exposure and markers overlapping as described.
Which metabolite was highest?
MEP, then MMP.
LMWP vs GPx/TBARS?
Positive associations.
Mixture effect on GSH?
Negative WQS association (p = 0.025).
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