Emotion circuits
Do fear circuits respond differently in women with PTSD?
Open access · cc by · source: Europe PMC
Women with PTSD showed more amygdala and insula activity than controls during an emotional distraction task, and their insula responded especially when they paid attention to fearful faces.
Study at a glance
- Design
- Case-control — Event-related fMRI during an emotional interference task (match faces or houses; fearful vs neutral faces attended or ignored), comparing women with PTSD to trauma-unexposed controls.
- N
- 32 women with PTSD from interpersonal trauma and 21 matched trauma-unexposed female controls; behavioural data came from a subset.
- Population
- Right-handed English-speaking women aged 18-55, unmedicated, with PTSD after interpersonal trauma, and healthy female controls.
- Outcome
- BOLD activation in amygdala and insula (and exploratory prefrontal regions) by group, attention and emotion; correlations with PTSD symptom clusters.
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Key findings
The PTSD group had higher left amygdala and left insula activity overall, regardless of whether faces were fearful. In the insula there was a three-way interaction: women with PTSD had more activity when attending than ignoring fearful faces, whereas controls showed the reverse. Default-mode prefrontal regions deactivated less in PTSD, and stronger re-experiencing symptoms went with less deactivation; behaviour did not differ reliably, with PTSD participants a non-significant 46 ms slower when attending fearful faces.
Methodology
Researchers scanned 32 women with PTSD after interpersonal trauma and 21 matched women without trauma. On each trial participants saw a pair of faces and a pair of houses and judged whether the pair on a cued axis matched, so the fearful or neutral faces were sometimes attended and sometimes ignored. They compared brain activity in the amygdala and insula, and explored prefrontal regions, between groups.
Limitations
The amygdala effect was a general group difference, not specific to fearful faces, so it does not show fear-selective hyperreactivity. There was no trauma-exposed group without PTSD, so the study cannot separate effects of the disorder from effects of trauma exposure. Only women with interpersonal trauma were tested, so results may not generalise to men or other trauma types, and the symptom correlations were exploratory.
How this study connects
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