Emotion circuits
Why do we remember upsetting things but forget their context?
Open access · cc by · source: Europe PMC
Negative images were remembered better on their own but linked less well to other images, and brain scans showed the amygdala tracking the first effect and a dampened hippocampus the second.
Study at a glance
- Design
- Human experiment — Within-subject fMRI paired-associate task: pairs of neutral, negative or mixed images were encoded, then cued recall of the partner was tested in the scanner and again in the reverse direction outside it; subsequent-memory and retrieval contrasts plus PPI connectivity.
- N
- N=20 · Twenty healthy student volunteers; item-memory fMRI analyses used 17 because three people had too few item misses in some conditions.
- Population
- Healthy right-handed university students, mean age 23
- Outcome
- Item recognition and associative (paired-associate) memory; amygdala and hippocampal activity and connectivity at encoding and retrieval
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Key findings
Negative images were recognised better than neutral ones, but any negative image in a pair reduced memory for the association compared with neutral-neutral pairs, though retrieving a negative partner was somewhat easier than a neutral one. At encoding, left anterior hippocampal activity predicted later associative memory and was reduced whenever a negative image was present, and hippocampal coupling with entorhinal cortex was stronger for neutral images. At retrieval, the amygdala responded more to recognised than forgotten negative items and to successful retrieval of negative partners, and at encoding it coupled more with lateral occipital visual cortex for negative images.
Methodology
Twenty students viewed 100 pairs of images during fMRI: pairs were both neutral, both negative, or mixed. About ten minutes later, in the scanner, each studied image cued them to recall its partner by choosing a written description; a second test outside the scanner cued the reverse direction. The researchers related brain activity during study and test to later item memory (recognising an image as seen) and associative memory (recalling its partner), and examined how amygdala and hippocampal connectivity changed with negative content.
Limitations
With only twenty participants, several key effects (the amygdala subsequent-item-memory effect, the hippocampal cue-valence effect at retrieval and both connectivity results) were reported at uncorrected thresholds or did not survive small-volume correction, and the authors note they may have been underpowered. The amygdala encoding effect was not specific to negative items, and hippocampal and amygdala activity were not inversely related, so the two systems are not shown to directly oppose each other. The study used a short delay, student volunteers and picture pairs, so links to traumatic memory and PTSD are theoretical extrapolations.
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