Chemical exposure
Phthalates track weaker grip in Korean elders
Open access · cc by · source: Europe PMC
Higher urinary DEHP and MnBP metabolites were inversely associated with handgrip strength in community-dwelling older adults, especially with a high omega-6/omega-3 diet.
How this study connects
Role on claims
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Evidence for the claim as stated.
Higher urinary DEHP and MnBP metabolites were inversely associated with handgrip strength in community-dwelling older adults, especially with a high omega-6/omega-3 diet.
Evidence for the claim as stated.
Urinary metabolites in one cohort are not a causal diagnosis, and matrix (dust vs urine vs serum) changes which compounds you see.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Urinary metabolites in one cohort are not a causal diagnosis, and matrix (dust vs urine vs serum) changes which compounds you see.
- Supports · Douching helps explain MEP disparities
Study at a glance
- Design
- Cohort — KEEP II repeated urinary phthalates and dynamometer grip in Korean elders
- N
- N=1253 · 1,253 noninstitutionalized elders; diet-stratified subset n=391
- Population
- Elderly adults in Seoul and Asan, Republic of Korea
- Outcome
- Handgrip strength associated with MEOHP, MEHHP, and MnBP
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
Phthalates track weaker grip in Korean elders
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
1,253 noninstitutionalized elderly citizens were recruited
We recruited 1,253 noninstitutionalized elderly citizens who regularly visited community welfare centers in Seoul and Asan, Republic of Korea, and volunteered to participate in the study.
Which cohort was studied?
The Korean Elderly Environmental Panel II (KEEP II) study is a repeated-measures study conducted between 2012 and 2015 to investigate the associations between environmental risk factors and health outcomes in the elderly.
Key findings
Log creatinine-adjusted MEOHP, MEHHP, and MnBP were inversely associated with right and left grip after confounder control, including multipollutant models. Geometric means were 15.48, 21.11, and 28.23 μg/L. Associations were stronger when the omega-6/omega-3 ratio was ≥8.81. Sex did not modify the link.
Methodology
KEEP II (2012–2015) repeatedly measured MEOHP, MEHHP, and MnBP plus dynamometer grip in 1,253 noninstitutionalized elders in Seoul and Asan, using creatinine-adjusted mixed models and diet-stratified analyses in 391 Seoul participants.
Limitations
Cross-sectional/repeated association is not proven muscle toxicity. Medical plastics could confound. Exact kilogram effect sizes sit in tables, and the sample is mostly healthy older women.
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