Chemical exposure
Pregnancy PFAS and lead track lower birth weight
Open access · cc by · source: Europe PMC
In Cincinnati’s HOME Study, PFAS, lead, and organophosphate pesticides associated with lower birth weight; phthalates and BPA did not.
How this study connects
Role on claims
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In Cincinnati’s HOME Study, PFAS, lead, and organophosphate pesticides associated with lower birth weight; phthalates and BPA did not.
Evidence for the claim as stated.
Study at a glance
- Design
- Cohort — Bayesian hierarchical linear models of gestational EDC biomarkers and birth weight in the HOME Study
- N
- N=272 · 272 of 389 singleton live births with complete covariates; biomarkers at ~16 and 26 weeks
- Population
- Mother–infant pairs in Cincinnati’s HOME Study
- Outcome
- Gestational PFAS, lead, and organophosphate pesticides associated with lower birth weight; phthalates and BPA did not
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Inspect source passages
Pregnancy PFAS and lead track lower birth weight
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
272 of 389 singleton live births (69.9%) had all covariates and were analyzed.
Of 389 singleton live births, 272 (69.9%) had all covariates and were included in analysis
The phthalates-and-BPA class averaged a 1 g birth-weight association.
The μ β posterior mean for the phthalates and BPA was 1 g with 95% CI (-20, 23)
Key findings
Nine phthalates plus BPA averaged +1 g per 10-fold exposure; the PFAS class averaged −11 g; all 5 PFAS trended toward lower weight; smoking cut birth weight 210 g.
Methodology
Used Bayesian hierarchical linear models (and LASSO/Elastic Net) on 272 of 389 singleton births with gestational biomarkers at ~16 and 26 weeks.
Limitations
Does not prove mechanisms, model chemical-class interactions, or capture nonlinear thresholds.
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