Persistent pollutants
Serum PFAS mixes reveal seafood vs product exposure
Open access · cc by · source: Europe PMC
Long-chain PFCAs mark seafood/whale diets, while PFHxS and N-EtFOSAA mark carpets and consumer products in children.
How this study connects
Role on claims
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Long-chain PFCAs mark seafood/whale diets, while PFHxS and N-EtFOSAA mark carpets and consumer products in children.
Evidence for the claim as stated.
PFAS profiles can separate sources but explain little variance. Faroese whalers' mixes were ~80% PFOS and separated on PC1 (51% of variance); children's profiles were richer in PFHxS and N-EtFOSAA. Hair mercury correlated with PFHpS, PFDA, PFOS and PFUnDA (ρ 0.35–0.61). In NHANES, carpets raised PFHxS 37.2% and seafood tracked PFNA, yet the models explained only 9–25% of PFAS variance.
Evidence for the claim as stated.
Study at a glance
- Design
- Cross-sectional — Serum PFAS profiles with PCA/clustering in Faroese groups and predictor models in NHANES/CHirP
- N
- N=2120 · NHANES 2005–06 n = 2,120; Faroe children n = 52, women n = 52, whalers n = 10; CHirP n = 151; NHANES 2011–12 n = 1,751
- Population
- Faroese children, women, and whalers plus US NHANES and CHirP participants
- Outcome
- Long-chain PFCAs mark seafood/whale diets, while PFHxS and N-EtFOSAA mark carpets and consumer products in children
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Inspect source passages
Serum PFAS mixes reveal seafood vs product exposure
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
First three PCA components explain 77% of serum PFAS variability
The first three components of the PCA explain 77% of the total variability in serum PFAS concentrations (Fig.
First PCA component explains 51% of the variability
The first PCA component explains 51% of the variability, and clearly separates whaling men from children and women.
Key findings
Whalers’ profiles were ~80% PFOS and separated on PC1 (51% of variance). Children had higher PFHxS and N-EtFOSAA. Hair mercury correlated with PFHpS, PFDA, PFOS, and PFUnDA (ρ 0.35–0.61). Carpets raised PFHxS 37.2% in NHANES. Seafood tracked PFNA in both US cohorts.
Methodology
Authors compared 15 PFASs in Faroese children, women, and whalers, ran PCA/clustering, and modeled NHANES 2005–06 and CHirP predictors such as seafood, carpets, and drinking water.
Limitations
NHANES models explained only 9–25% of PFAS variance. Toxicokinetics and time trends can mimic source differences. CHirP detected only four PFASs in >50% of people.
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