Metabolism
Folliculin tunes mTORC1 toward TFE3
Open access · cc by · source: Europe PMC
FLCN–RagC signaling makes mTORC1 substrate-selective for TFE3 phosphorylation under amino-acid cues.
Key findings
TFE3 phosphorylation depends strongly on amino acids; FLCN promotes RagC activity to recruit TFE3.
Methodology
Manipulated amino acids, GATOR, FLCN, and RagC in C2C12 cells and read TFE3 phosphorylation/localization.
Limitations
Mostly cell-culture mechanism; organismal physiology needs separate tests.
How this study connects
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