Chemical exposure
Phthalates, thyroid hormones, and adult blood lipids
Open access · cc by · source: Europe PMC
In 222 Taiwanese adults, urinary phthalate metabolites tracked with thyroid hormones and lipid markers; T4 appeared to sit on the path from DEHP metabolites to HDL-C, but that mediation interval included the null.
Key findings
MMP associated with lower LDL-C; MEP with lower total cholesterol; ΣDEHP metabolites with higher HDL-C. T4 was estimated to mediate 32.2% of the ΣDEHPm–HDL-C link, but that indirect effect was not statistically significant.
Methodology
Authors measured nine urinary phthalate metabolites, thyroid hormones (including T4 and TBG), and fasting lipids in 222 adults, then used regression and mediation analysis (plus BKMR mixtures) to test whether thyroid function links phthalates to lipids.
Limitations
Cross-sectional mediation cannot establish that phthalates change lipids via thyroid hormones; the headline T4 path was not significant and the sample is modest.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Not yet placed on a claim. This paper has study layers, but no concept page yet cites it as support, challenge, or qualifier.
Related papers in this topic
Same topic cluster — not a recommendation engine.