Host–pathogen
Which genes does P. gingivalis need to grow?
Open access · cc by · source: Europe PMC
A near-saturating Tn-seq screen finds ~463 (~22%) P. gingivalis genes putatively essential on blood agar.
Key findings
463 genes (22%) are putatively essential; most have essential homologues elsewhere, while ~21% may be species/niche-specific essentials.
Methodology
Authors built a Mariner Tn-seq library in P. gingivalis ATCC 33277 and scored insertion under-representation to call genes required for in vitro survival on blood agar.
Limitations
Blood-agar essentials ≠ all virulence genes in the host; different selective pressures will reveal other gene sets.
How this study connects
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