Host–pathogen
Can blocking host protein on catheters prevent CAUTI?
Open access · cc by · source: Europe PMC
Liquid-infused silicone catheters reduced host-protein deposition (~6.5-fold for secreted proteins) and lowered microbial colonization and dissemination in a mouse CAUTI model.
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Can blocking host protein on catheters prevent CAUTI?
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CAUTI accounts for ~40% of hospital-acquired infections.
The most common complication is catheter-associated urinary tract infection (CAUTI), which accounts for 40% of all hospital-acquired infections ( Andersen and Flores-Mireles, 2019 ; Feneley et al., 2015 ).
Host-secreted protein deposition on LIS catheters was ~6.5-fold lower than UM catheters.
Finally, the deposition of other host-secreted proteins on LIS-catheters was around 6.5-fold less then UM-catheters.
Key findings
Fg benefits E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, A. baumannii, and C. albicans. LIS catheters reduced protein deposition and decreased colonization on catheters, in bladders, and dissemination; other host-secreted proteins were ~6.5-fold lower than unmodified catheters.
Methodology
Showed fibrinogen deposition aids multiple uropathogens, then tested liquid-infused silicone catheters in mouse CAUTI to cut host-protein scaffolds and measured colonization plus surface proteomics.
Limitations
Mouse CAUTI efficacy is not yet a human clinical trial; durability, biocompatibility, and real-world infection rates remain to be proven.
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