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Smallpox, steamships, and two port cities

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Brabin compares Boston and Liverpool's 1901–5 smallpox epidemics, arguing steamship traffic linked peak US incidence to Liverpool while Hope and Durgin used surveillance, isolation and ring vaccination later reused in global eradication.

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An Analysis of the United States and United Kingdom Smallpox Epidemics (1901-5) - The Special Relationship that Tested Public Health Strategies for Disease Control

Brabin B · Medical history · 2020

doi.org/10.1017/mdh.2019.74Read the full paper ↗2 citationscc by

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Smallpox, steamships, and two port cities

These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.

Rapid transatlantic steamers after 1860 guaranteed American–United Kingdom transmission.

With the advent of rapid transatlantic steamers after 1860 American–United Kingdom transmission was guaranteed

How long had Atlantic smallpox travel lasted?

Smallpox was regularly transmitted across the Atlantic after its arrival from tropical Africa in the fifteenth century. Many other diseases failed to make
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What they did

A comparative historical analysis of the US and UK smallpox epidemics of 1901–5, especially Boston and Liverpool, using public-health reports, port records, and accounts of Medical Officers Hope and Durgin, including anti-vaccination politics.

What they found

After 1860, rapid steamers guaranteed transatlantic smallpox passage. Incubating travellers delayed recognition. Despite 1901 contact between Liverpool Port Authority and the USPHS, maritime surveillance was not heightened. Both cities used screening, isolation, quarantine, contact tracing and ring vaccination; Boston's anti-vaccinationists were especially vehement. Liverpool's post-exposure vaccination helps explain a rapid 1903 fall.

The limits

What it doesn't show

This is not a modern vaccine RCT. Historical protective-effect inferences from Liverpool data are not a new serological survey of 1901 populations.

Key terms

Ring vaccination
Selective vaccination of contacts living near cases, later used in WHO smallpox eradication.
Incubating travellers
Infected persons not yet showing disease, who seeded port epidemics after steamship arrival.
Edward William Hope
Liverpool Medical Officer of Health during the epidemic, counterpart to Boston's Samuel Holmes Durgin.
Transatlantic steam traffic
Post-1860 rapid passage that made US–UK smallpox transfer routine.

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The paired epidemic cities are?

Common questions

Which cities are paired?

Boston and Liverpool, both large ports with late recognition of incubating cases.

What is ring vaccination here?

Selective vaccination around cases, later used in global eradication.

Was maritime surveillance stepped up in 1901?

Despite communications, there is no record of heightened surveillance in either city or country.

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