B. dorei rises before T1D autoimmunity
Bacteroides dorei dominates the gut microbiome before autoimmunity in high-risk Finnish children.
Source
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes
What they did
Sequenced 947 stool samples from 76 HLA-risk children (29 seroconverters vs 47 controls) in a longitudinal DIPP cohort.
What they found
Cases show B. dorei dominance prior to persistent autoantibodies (mean diagnosis age 16.8 months).
The limits
What it doesn't show
Does not prove B. dorei causes T1D; observational association.
Key terms
- Bacteroides dorei
- Gut bacterium enriched before autoimmunity.
- T1D
- Type 1 diabetes.
- Seroconversion
- Appearance of disease autoantibodies.
- HLA-DQB1
- Genetic risk locus for T1D.
- DIPP
- Finnish Type 1 Diabetes Prediction and Prevention Study.
- 16S / metagenome
- Microbiome sequencing approaches.
Flashcards
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Stools:
Common questions
Stool samples?
947.
Children?
76.
Cases?
29 seroconverters.
Key taxon?
Bacteroides dorei.
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