B. dorei rises before T1D autoimmunity

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Bacteroides dorei dominates the gut microbiome before autoimmunity in high-risk Finnish children.

Source

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes

Davis-Richardson AG, Ardissone AN, Dias R, et al. · Frontiers in microbiology · 2014

doi.org/10.3389/fmicb.2014.00678 Read the full paper ↗227 citationscc by

Study at a glance

Design: Cohort — Longitudinal DIPP stool sequencing in HLA-risk children before T1D autoimmunity
N: N=76 · 947 stool samples; 29 seroconverters vs 47 autoantibody-negative controls
Population: HLA-DQB1 moderate-to-high-risk children in DIPP
Outcome: Gut microbiota (B. dorei dominance) prior to persistent T1D autoantibodies

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B. dorei rises before T1D autoimmunity

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947 stool samples from 76 children.

DNA from 947 stool samples from 76 number children having the moderate (odds-ratio <5) to high risk (odds-ratio 5–15) for T1D according to their HLA-DQB1 genotype, which is known to increase T1D risk, was sequenced.

29 subjects developed persistent autoantibodies.

Twenty-nine subjects developed at least three persistent T1D-relative autoantibodies (mean age at diagnosis = 16.8 months, SE = 2.03), which collectively confers >95% risk of clinical T1D diagnosis.

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What they did

Sequenced 947 stool samples from 76 HLA-risk children (29 seroconverters vs 47 controls) in a longitudinal DIPP cohort.

What they found

Cases show B. dorei dominance prior to persistent autoantibodies (mean diagnosis age 16.8 months).

The limits

What it doesn't show

Does not prove B. dorei causes T1D; observational association.

Key terms

Bacteroides dorei: Gut bacterium enriched before autoimmunity.
T1D: Type 1 diabetes.
Seroconversion: Appearance of disease autoantibodies.
HLA-DQB1: Genetic risk locus for T1D.
DIPP: Finnish Type 1 Diabetes Prediction and Prevention Study.
16S / metagenome: Microbiome sequencing approaches.

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Stools:

Common questions

Stool samples?

947.

Children?

76.

Cases?

29 seroconverters.

Key taxon?

Bacteroides dorei.