Gamma-made Ag–Se nanoparticles carrying cefotaxime
Radiolytic Ag, Se, and Ag–Se nanoparticles (about 11–21 nm) are characterized and loaded with cefotaxime for synergistic antimicrobial tests.
Source
Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism
What they did
Authors reduced 1.0 mM AgNO3 and/or Na2SeO3 with gamma rays (15 kGy Ag/Ag–Se; 10 kGy Se), tracked UV-vis (406/518/420 nm), sized particles by DLS/HR-TEM/XRD, and combined them with cefotaxime for antimicrobial/antibiofilm assays.
What they found
Spherical particles averaging 10.95 nm (Ag), 20.54 nm (Se), and 12.69 nm (Ag–Se). Optical densities were recorded at 406, 518, and 420 nm. A radiolytic reduction mechanism at those kGy doses is proposed.
The limits
What it doesn't show
This is not a randomized clinical UTI trial; membrane-leakage/MIC biology is secondary to the materials characterization for chemistry teaching.
Key terms
- Gamma radiolysis
- Ionizing radiation that generates reducing radicals to make metal nanoparticles.
- Bimetallic Ag–Se NPs
- Mixed silver–selenium nanoparticles from co-reduction of Ag+ and SeO32−.
- Cefotaxime (CFM)
- β-lactam antibiotic incorporated with the NPs.
- SPR wavelengths
- 406 nm Ag, 518 nm Se, 420 nm Ag–Se used to track formation.
- kGy dose
- 15 kGy for Ag/Ag–Se and 10 kGy for Se NPs.
Flashcards
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Average Ag NP size is about:
Common questions
Average TEM sizes?
10.95, 20.54, and 12.69 nm for Ag, Se, Ag–Se.
Radiation doses?
15 kGy (Ag, Ag–Se) and 10 kGy (Se).
UV-vis wavelengths?
406, 518, 420 nm.
Precursor concentration?
1.0 mM salts.
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