Folliculin tunes mTORC1 toward TFE3
FLCN–RagC signaling makes mTORC1 substrate-selective for TFE3 phosphorylation under amino-acid cues.
Source
Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3
What they did
Manipulated amino acids, GATOR, FLCN, and RagC in C2C12 cells and read TFE3 phosphorylation/localization.
What they found
TFE3 phosphorylation depends strongly on amino acids; FLCN promotes RagC activity to recruit TFE3.
The limits
What it doesn't show
Mostly cell-culture mechanism; organismal physiology needs separate tests.
Key terms
- mTORC1
- Nutrient-sensing kinase complex.
- Folliculin (FLCN)
- GAP regulator acting via RagC.
- RagC
- Rag GTPase aiding lysosomal recruitment.
- TFE3
- Transcription factor for lysosome biogenesis.
- Amino-acid sensing
- Nutrient input to mTORC1.
- GATOR
- Complex regulating Rag pathway.
Flashcards
Want these cards to stick?
Save the deck to NoteFren and study it with spaced repetition.
Quiz yourself
Topic:
Common questions
Kinase?
mTORC1.
Adaptor focus?
FLCN/RagC.
Substrate?
TFE3.
Key cue?
Amino acids.
More on Metabolism