Gut microbes, blood metabolites, and metabolic traits
In 531 METSIM men, gut microbiota associate with plasma metabolites and metabolic-syndrome-relevant traits.
Source
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
What they did
Systematically analyzed gut microbiome and metabolically relevant traits in a METSIM subset of Finnish men.
What they found
Gut microbes relate to host plasma metabolites and metabolic traits, supporting microbiota as a factor alongside genetics and lifestyle.
The limits
What it doesn't show
Associations in middle-aged men are not universal causal proof or a treatment RCT.
Key terms
- METSIM
- Metabolic Syndrome in Men cohort (Kuopio, Finland).
- Gut microbiota
- Intestinal microbial community.
- Plasma metabolites
- Circulating small molecules.
- Metabolic syndrome traits
- Cardiometabolic risk phenotypes.
- Microbial metabolites
- Microbe-produced compounds affecting the host.
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Subset N:
Common questions
Subset size?
531 men.
Full METSIM?
10,197 individuals.
What was linked?
Microbes, plasma metabolites, metabolic traits.
Where?
Kuopio, Eastern Finland.
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