Gut microbes, blood metabolites, and metabolic traits
In 531 METSIM men, gut microbiota associate with plasma metabolites and metabolic-syndrome-relevant traits.
Source
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Study at a glance
- Design
- Cross-sectional — METSIM subset microbiome–metabolite–metabolic trait association analysis
- N
- N=531 · 531 middle-aged Finnish men from the METSIM cohort (parent cohort 10,197)
- Population
- Middle-aged Finnish men in METSIM
- Outcome
- Associations of gut microbiota with plasma metabolites and metabolic traits
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
Gut microbes, blood metabolites, and metabolic traits
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Analysis included 531 middle-aged Finnish men.
In the current study we performed systematic analysis of the gut microbiome and a variety of metabolically relevant traits in 531 middle-aged Finnish men, collected from the general population of the METabolic Syndrome In Men (METSIM) study [].
The METSIM cohort totals 10,197 individuals.
The METSIM cohort (total 10,197 individuals) is one of the largest single-site population based cohorts and was collected from Kuopio, Eastern Finland, and established to evaluate genetic determinants of metabolic traits in middle-aged men.
What they did
Systematically analyzed gut microbiome and metabolically relevant traits in a METSIM subset of Finnish men.
What they found
Gut microbes relate to host plasma metabolites and metabolic traits, supporting microbiota as a factor alongside genetics and lifestyle.
The limits
What it doesn't show
Associations in middle-aged men are not universal causal proof or a treatment RCT.
Key terms
- METSIM
- Metabolic Syndrome in Men cohort (Kuopio, Finland).
- Gut microbiota
- Intestinal microbial community.
- Plasma metabolites
- Circulating small molecules.
- Metabolic syndrome traits
- Cardiometabolic risk phenotypes.
- Microbial metabolites
- Microbe-produced compounds affecting the host.
Flashcards
0 of 10 answers reviewed
Research intelligence for this paper
See its role on concept claims, tensions it is part of, placement history, and related discoveries.
Quiz yourself
Subset N:
Common questions
Subset size?
531 men.
Full METSIM?
10,197 individuals.
What was linked?
Microbes, plasma metabolites, metabolic traits.
Where?
Kuopio, Eastern Finland.
More on Microbiome