Circadian biology
Tiling arrays reveal plant circadian RNAs
Open access · cc by · source: Europe PMC
Genome tiling arrays uncover extensive circadian-regulated transcription across the Arabidopsis genome.
How this study connects
Role on claims
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Known clock genes cycle as expected; many additional exons/ncRNA features show circadian rhythms.
Evidence for the claim as stated.
Study at a glance
- Design
- Animal / in-vitro — Arabidopsis genome tiling arrays on a 2-day circadian time course
- N
- N=12 · 12 samples at 4-hour resolution over 2 days
- Population
- Arabidopsis thaliana plants under circadian free-run
- Outcome
- Extensive circadian transcription including exons, introns, and natural antisense transcripts beyond annotated clock genes
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Inspect source passages
Tiling arrays reveal plant circadian RNAs
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Arabidopsis thaliana.
Earth's rotation. In addition to reacting directly to external stimuli, many organisms time their behavior in anticipation of periodic changes in the environment.
Whole-genome tiling arrays.
The endogenous timing mechanism known as circadian clocks is widespread across life and is primarily based on interlocking transcriptional feedback loops and regulated protein turnover [].
Key findings
Known clock genes cycle as expected; many additional exons/ncRNA features show circadian rhythms.
Methodology
Sampled a 2-day circadian time course at 4-hour resolution on whole-genome tiling arrays.
Limitations
Two-day series limits period precision versus longer time courses.
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