Circadian biology
How does food reset the liver clock?
Open access · cc by · source: Europe PMC
The gut incretin oxyntomodulin (OXM) links food intake to resetting of the hepatic circadian clock and metabolism.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Multiple empirical papers in this library examine circadian biology with mechanistic biological findings.
Evidence for the claim as stated.
OXM can couple food intake to hepatic clock resetting; eating in the rest phase risks internal circadian desynchrony relevant to shiftwork metabolism.
Evidence for the claim as stated.
Systems and scales differ across circadian biology studies (species, tissues, methods), so mechanisms should not be over-generalised.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Systems and scales differ across circadian biology studies (species, tissues, methods), so mechanisms should not be over-generalised.
Study at a glance
- Design
- Animal / in-vitro — Organotypic liver-slice and in-vivo assays of food-related OXM as a liver-clock Zeitgeber
- N
- Mouse liver-clock resetting experiments — no single primary analytic N in stored text
- Population
- Mouse liver tissue/slices and related in-vivo models
- Outcome
- Hepatic circadian clock resetting by oxyntomodulin
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
How does food reset the liver clock?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Which peptide links gut food intake to liver clock resetting?
identified the incretin peptide OXM as a potential direct link between food intake in the gut and resetting of hepatic clock and metabolic gene transcription.
What happens if eating occurs in the rest phase?
eating during the normal rest phase leads to a state of internal circadian desynchrony which has been suggested to underlie metabolic deregulation under shiftwork conditions (; ; ).
Key findings
OXM can couple food intake to hepatic clock resetting; eating in the rest phase risks internal circadian desynchrony relevant to shiftwork metabolism.
Methodology
Investigated food-related Zeitgebers for peripheral clocks and identified OXM as a candidate signal from gut to liver clock resetting.
Limitations
Not a human shiftwork clinical trial; glucose-dependent hormones are not the only food cues.
Related papers in this topic
Same topic cluster — not a recommendation engine.