Circadian biology
How does food reset the liver clock?
Open access · cc by · source: Europe PMC
The gut incretin oxyntomodulin (OXM) links food intake to resetting of the hepatic circadian clock and metabolism.
Study at a glance
- Design
- Animal / in-vitro — Organotypic liver-slice and in-vivo assays of food-related OXM as a liver-clock Zeitgeber
- N
- Mouse liver-clock resetting experiments — no single primary analytic N in stored text
- Population
- Mouse liver tissue/slices and related in-vivo models
- Outcome
- Hepatic circadian clock resetting by oxyntomodulin
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
OXM can couple food intake to hepatic clock resetting; eating in the rest phase risks internal circadian desynchrony relevant to shiftwork metabolism.
Methodology
Investigated food-related Zeitgebers for peripheral clocks and identified OXM as a candidate signal from gut to liver clock resetting.
Limitations
Not a human shiftwork clinical trial; glucose-dependent hormones are not the only food cues.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Multiple empirical papers in this library examine circadian biology with mechanistic biological findings.
Evidence for the claim as stated.
OXM can couple food intake to hepatic clock resetting; eating in the rest phase risks internal circadian desynchrony relevant to shiftwork metabolism.
Evidence for the claim as stated.
Systems and scales differ across circadian biology studies (species, tissues, methods), so mechanisms should not be over-generalised.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Systems and scales differ across circadian biology studies (species, tissues, methods), so mechanisms should not be over-generalised.
Related papers in this topic
Same topic cluster — not a recommendation engine.