Nanomaterials
XPS and SIMS map thioglucose SAMs on gold
Open access · cc by · source: Europe PMC
Thio-glucose binds gold through Au–S; flat films pack better than citrate AuNPs, and ToF-SIMS sees TG–MBP pocket fragments.
Study at a glance
- Design
- Other — XPS/ToF-SIMS of thio-glucose on AuNPs and Au films before/after maltose-binding protein
- N
- Surface-chemistry analysis of ~15 nm AuNPs — no sample N
- Population
- Thio-glucose–functionalized gold nanoparticles and films
- Outcome
- Bound vs unbound thiol fractions and protein uptake differences
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
S2p at 162 eV proves chemisorption; C–O (286.5 eV) rises ~6-fold on films. NPs retain ~30% unbound thiol and lower TG density, hence weaker MBP uptake. SIMS peaks at 358 and 375 u mark TG–pocket complexes.
Methodology
Authors made ~15 nm citrate AuNPs, assembled 1-β-D-thio-glucose on NPs and sputtered Au films, then used XPS and ToF-SIMS before/after maltose-binding protein.
Limitations
No calibrated binding constant; Ti-supported NP films confound O/C; biosensor performance is not quantified.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
This library holds 12 empirical chemistry papers on nanomaterials with isolated findings, rates or spectra rather than reviews.
Evidence for the claim as stated.
Thio-glucose binds gold through Au–S; flat films pack better than citrate AuNPs, and ToF-SIMS sees TG–MBP pocket fragments.
Evidence for the claim as stated.
Size and support change activity as much as composition; a TEM image is not a mechanism.
Evidence for the claim as stated.
XPS can prove chemisorption of a thiol sugar on gold and still not give a binding constant. On ~15 nm citrate AuNPs and sputtered Au films, S 2p at 162 eV marks Au–S; C–O (286.5 eV) rises about six-fold on films after 1-β-D-thio-glucose. Nanoparticles retain ~30% unbound thiol and lower thioglucose density, hence weaker maltose-binding-protein uptake; SIMS peaks at 358 and 375 u mark TG–pocket complexes. No calibrated Kd is reported.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Size and support change activity as much as composition; a TEM image is not a mechanism.
Related papers in this topic
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