Topic
Cell signalling research, explained
7 open-access cell signalling studies, each with a flashcard deck and a quiz.
- When does Wnt5a turn β-catenin signaling on or off?
Purified Wnt5a can activate or inhibit β-catenin–TCF signaling depending on which Frizzled/receptor context is present.
- Shared class A GPCR activation path
Class A GPCRs share a conserved residue-contact rearrangement pathway from ligand pocket to G-protein site.
- CPK3/6 mediate ABA guard-cell signaling
Calcium-dependent kinases CPK3 and CPK6 act in ABA control of guard-cell anion/Ca²⁺ channels and stomatal closure.
- How specific are bacterial two-component pathways?
Caulobacter histidine kinases prefer their cognate response regulators in vitro; phosphotransfer profiling reveals conserved pathways controlling growth.
- HSP90 family across kingdoms
Comparative genomics maps 103 HSP90-family genes across 32 genomes and deep phylogenetic diversity.
- LOX1 oxylipins close stomata in defense
Guard-cell LOX1 drives ABA-independent stomatal closure that limits Pseudomonas colonization.
- How does USP8 turn on Smoothened?
USP8 deubiquitinates Smoothened, promoting Hh-dependent cell-surface accumulation and signaling while limiting early-endosome localization.