How does food reset the liver clock?
The gut incretin oxyntomodulin (OXM) links food intake to resetting of the hepatic circadian clock and metabolism.
Source
Oxyntomodulin regulates resetting of the liver circadian clock by food
Study at a glance
- Design
- Animal / in-vitro — Organotypic liver-slice and in-vivo assays of food-related OXM as a liver-clock Zeitgeber
- N
- Mouse liver-clock resetting experiments — no single primary analytic N in stored text
- Population
- Mouse liver tissue/slices and related in-vivo models
- Outcome
- Hepatic circadian clock resetting by oxyntomodulin
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Inspect source passages
How does food reset the liver clock?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Which peptide links gut food intake to liver clock resetting?
identified the incretin peptide OXM as a potential direct link between food intake in the gut and resetting of hepatic clock and metabolic gene transcription.
What happens if eating occurs in the rest phase?
eating during the normal rest phase leads to a state of internal circadian desynchrony which has been suggested to underlie metabolic deregulation under shiftwork conditions (; ; ).
What they did
Investigated food-related Zeitgebers for peripheral clocks and identified OXM as a candidate signal from gut to liver clock resetting.
What they found
OXM can couple food intake to hepatic clock resetting; eating in the rest phase risks internal circadian desynchrony relevant to shiftwork metabolism.
The limits
What it doesn't show
Not a human shiftwork clinical trial; glucose-dependent hormones are not the only food cues.
Key terms
- Oxyntomodulin (OXM)
- Gut incretin peptide implicated in liver clock resetting.
- Peripheral clock
- Circadian oscillator in organs outside the SCN.
- Food entrainment
- Resetting of clocks by feeding time.
- Zeitgeber
- External cue that resets circadian clocks.
- Internal desynchrony
- Misalignment among body clocks.
Flashcards
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Key peptide:
Common questions
Which peptide is highlighted?
Oxyntomodulin.
Which organ clock?
Liver.
Problem with rest-phase eating?
Internal circadian desynchrony.
Is glucose the only cue?
No—food entrainment is not exclusively glucose-dependent.
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