Vaccination
Shingles vaccine cut zoster by about half
Open access · cc by · source: Europe PMC
In older US adults, herpes zoster vaccination showed ~48% effectiveness against incident zoster and ~59–62% against post-herpetic neuralgia.
How this study connects
Role on claims
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Overall VE ~48% against incident zoster; 62% against PHN at 30 days and 59% at 90 days; uptake was only 3.9% and lower in Black and low-income groups.
Evidence for the claim as stated.
Study at a glance
- Design
- Cohort — US Medicare beneficiaries followed for zoster vaccination and incident zoster/PHN
- N
- N=766330
- Population
- Eligible older US Medicare beneficiaries
- Outcome
- Vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
Shingles vaccine cut zoster by about half
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Overall VE 48% against incident zoster; 62%/59% against PHN.
Overall VE of 48% was demonstrated against incident herpes zoster, 62% against PHN after 30 d and 59% against PHN after 90 d.
29,785 of 766,330 (3.9%) were vaccinated.
Of the 766,330 eligible participants, 29,785 (3.9% of people; 2.1% of person-time) had herpes zoster vaccination during the study period.
Key findings
Overall VE ~48% against incident zoster; 62% against PHN at 30 days and 59% at 90 days; uptake was only 3.9% and lower in Black and low-income groups.
Methodology
A cohort of 766,330 eligible older Medicare beneficiaries was followed for zoster vaccination and incident herpes zoster/PHN, estimating adjusted vaccine effectiveness.
Limitations
Randomized efficacy in this dataset, or precise VE in highly immunosuppressed subgroups (small numbers).
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