Pathogenicity factors in Naegleria fowleri
Whole-genome analysis of N. fowleri highlights candidate pathogenicity factors for brain infection.
Source
Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri
What they did
Sequenced and assembled the N. fowleri genome and compared features relevant to virulence.
What they found
~30 Mb AT-rich genome assembled; candidate pathogenicity gene sets identified for follow-up.
The limits
What it doesn't show
Genome candidates need functional validation in infection models.
Key terms
- Naegleria fowleri
- Free-living amoeba causing PAM.
- PAM
- Primary amoebic meningoencephalitis.
- Pathogenicity factor
- Gene/product aiding virulence.
- AT-rich
- Low GC genome composition.
- Free-living amoeba
- Environmental protist that can infect.
- Genome assembly
- Reconstructing chromosomes from reads.
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Common questions
Organism?
N. fowleri.
Disease?
PAM.
Genome size?
~30 Mb.
Focus?
Pathogenicity factors.
More on Host–pathogen