Topic
Host–pathogen research, explained
13 open-access host–pathogen studies, each with a flashcard deck and a quiz.
- How does malaria’s blood-stage transcriptome unfold?
Plasmodium falciparum’s 48-hour intraerythrocytic cycle was profiled hourly, revealing tightly staged gene-expression programs after RBC invasion.
- Apical-out enteroids for pathogen access
Suspending human enteroids without ECM flips polarity so microbes can meet the apical face.
- Can a bedside score flag deadly viral pneumonia?
In 528 viral pneumonia admissions, MuLBSTA (cut-off 12) stratified 90-day mortality better than CURB-65 (AUROC 0.773 vs 0.717).
- How open is the Listeria pan-genome?
Eleven new genomes spanning serotypes show a stable but open pan-genome with nine hypervariable hotspots dominated by mobile elements.
- LN DCs shelter antibiotic-tolerant Salmonella
Slow-growing Salmonella in cecum lymph-node dendritic cells survive ciprofloxacin therapy.
- Which genes does P. gingivalis need to grow?
A near-saturating Tn-seq screen finds ~463 (~22%) P. gingivalis genes putatively essential on blood agar.
- How do resistant banana roots respond to Fusarium?
Root transcriptomes differ between resistant and susceptible Cavendish bananas after Fusarium oxysporum TR4 infection.
- ATR inhibitor blocks SARS-CoV-2
DDR/ATR inhibitor berzosertib potently blocks SARS-CoV-2 replication in cell culture.
- PD-1 blockade reactivates TB via TNF
Anti-PD-1 immunotherapy can reactivate tuberculosis through TNF-α dysregulation.
- Does red light help tomatoes fight bacteria?
Tomato resistance to DC3000 peaks at 8:00 AM, bottoms at 8:00 PM, and is strongly enhanced by red light.
- Pathogenicity factors in Naegleria fowleri
Whole-genome analysis of N. fowleri highlights candidate pathogenicity factors for brain infection.
- Can blocking host protein on catheters prevent CAUTI?
Liquid-infused silicone catheters reduced host-protein deposition (~6.5-fold for secreted proteins) and lowered microbial colonization and dissemination in a mouse CAUTI model.
- Do ‘single-cell’ Mtb preps change macrophage results?
Gentle sonication made Mtb hyperinflammatory (TLR2-high IL-1β/TNF) yet still replicative in macrophages, while filtering blunted inflammation and attenuated intracellular survival — so prep method can rewrite host–pathogen readouts.