Can blocking host protein on catheters prevent CAUTI?
Liquid-infused silicone catheters reduced host-protein deposition (~6.5-fold for secreted proteins) and lowered microbial colonization and dissemination in a mouse CAUTI model.
Source
Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections
Inspect source passages
Can blocking host protein on catheters prevent CAUTI?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
CAUTI accounts for ~40% of hospital-acquired infections.
The most common complication is catheter-associated urinary tract infection (CAUTI), which accounts for 40% of all hospital-acquired infections ( Andersen and Flores-Mireles, 2019 ; Feneley et al., 2015 ).
Host-secreted protein deposition on LIS catheters was ~6.5-fold lower than UM catheters.
Finally, the deposition of other host-secreted proteins on LIS-catheters was around 6.5-fold less then UM-catheters.
What they did
Showed fibrinogen deposition aids multiple uropathogens, then tested liquid-infused silicone catheters in mouse CAUTI to cut host-protein scaffolds and measured colonization plus surface proteomics.
What they found
Fg benefits E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, A. baumannii, and C. albicans. LIS catheters reduced protein deposition and decreased colonization on catheters, in bladders, and dissemination; other host-secreted proteins were ~6.5-fold lower than unmodified catheters.
The limits
What it doesn't show
Mouse CAUTI efficacy is not yet a human clinical trial; durability, biocompatibility, and real-world infection rates remain to be proven.
Key terms
- CAUTI
- Catheter-associated urinary tract infection; ~40% of hospital-acquired infections.
- Fibrinogen (Fg)
- Host serum protein deposited on catheters that microbes use as a binding scaffold.
- LIS catheter
- Liquid-infused silicone catheter designed to resist host-protein deposition.
- UM catheter
- Unmodified catheter comparator in deposition/colonization assays.
- Antibiotic-sparing
- Intervention aiming to reduce infection without relying on antimicrobial impregnation.
- Uropathogen
- Microbe capable of causing urinary tract infection, including bacteria and Candida.
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Quiz yourself
CAUTIs account for roughly what share of HAIs?
Common questions
How common are CAUTIs among HAIs?
About 40% of hospital-acquired infections.
What catheter strategy was tested?
Liquid-infused silicone (LIS) to reduce host-protein deposition.
Effect on secreted host proteins?
About 6.5-fold less deposition vs unmodified catheters.
Infection readout timing?
Mice sacrificed at 24 hours post infection.
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