Topic
Gene expression research, explained
13 open-access gene expression studies, each with a flashcard deck and a quiz.
- How do microRNAs recognize their targets?
Sites with as little as seven base pairs matching the miRNA 5′ end can confer regulation; such 5′-dominant sites are common in conserved 3′ UTRs.
- Why do identical cells make different amounts of mRNA?
Mammalian genes switch rarely between ON and OFF, so intrinsically random transcriptional bursts create large cell-to-cell mRNA differences.
- Cataloging mammalian circular RNAs
Thousands of mammalian circRNAs arise by back-splicing and can be quantified across ENCODE cell types.
- MYB transcription-factor families in plants
Rice and Arabidopsis encode large MYB families dominated by R2R3 types with distinct expression patterns.
- What marks definitive endoderm progenitors in hESCs?
Single-cell RNA-seq separates definitive endoderm progenitors and links metabolism/hypoxia to DE differentiation.
- FLI1 circRNA FECR1 drives metastasis
Exonic circular RNA FECR1 binds the FLI1 promoter and epigenetically activates FLI1 in breast cancer.
- Where does cells minimize expression noise?
Yeast minimizes protein-expression noise preferentially for essential genes and protein-complex subunits, supporting that noise is generally harmful.
- Do SNPs prove exonic splicing enhancers are real?
Human polymorphism patterns validate computationally predicted ESEs and show splicing constrains exon evolution.
- Multi-tissue networks behind obesity biology
Adipose–hypothalamus coexpression subnetworks, including circadian genes, associate with obesity-related biology beyond single-tissue views.
- Pea aphid miRNAs and plasticity
Pea aphids encode dozens of miRNAs whose expression tracks phenotypic plasticity.
- Atlantic cod heat-shock gene responses
Heat shock elevates cortisol and rewires chaperone and stress-gene expression in Atlantic cod tissues.
- How does fish liver gene expression change under confinement stress?
Microarrays track the time course of gilthead sea bream liver transcriptional responses after confinement stress linked to cortisol biology.
- What do co-fermenting yeasts express together?
In balanced continuous co-culture, L. thermotolerans contributes ~24% of anaerobic reads vs ~8% aerobically.